Notice ID
2cb817f684c97710cbcc9a09d7d388b6
The National Institute of Mental Health NIMH proposes to issue solicitation No NIMH01DN0018 entitled Mouse Neuroscience Phenotyping and Distributing Center as a full and open competitive procurement under NAICS Code 541710 The NIMH proposed to award a one year contract with five one year options Some aspects of the Statement of Work SOW will be reimbursed on a fixed unit price basis while other aspects of the SOW will be reimbursed on a cost basis With the elucidation of the complete draft sequence of the human and other mammalian genomes the next challenge is to conduct largescale functional analyses of these genomes to greatly enhance our understanding of neurobiology The laboratory mouse plays a pivotal role in human functional genomic insofar as mouse strains carrying mutations have provided useful models for human diseases RFA MH99007 Mouse Mutagenesis and Phenotyping Nervous System and Behavior was issued in 1999 to establish neurosciencefocused facilities for largescale efficient wholegenome mutagenesis in order to promote the systematic and comprehensive functional analysis of neurobiological and behavioral phenotypes in the mouse Cooperative Agreements for three largescale mutagenesis and phenotyping facilities that focus on abnormalities in nervous system function and behavior were funded under the RFA A major goal of this initiative is to provide the scientific community with new research resources ie mutant animals in a timely fashion The expected production of mutants generated by the three neurosciencefocused mutagenesis facilities exceeds the capacity of existing mouse storage and distribution facilities In order to realize the full potential for the scientific community of mutants produced in the three mutagenesis facilities the NIMH is seeking to establish a largescale phenotyping and distribution virtual center The virtual center shall be comprised of a network of investigators with expertise in different phenotypic domains databasebioinformatics experts who can construct a stateoftheart database in response to the needs of the neuroscience and behavioral communities and adequate capacity to maintain and distribute mutant strains The specific functions to be performed by this virtual center include 1 confirmatory phenotyping of various nervous system functions and complex behaviors in mutant mice received from the three mutagenesis facilities 2 maintenance of mutant strains as live animals and cryopreserved materials embryos or ovaries and sperm 3 wide distribution to the scientific community of mutant strains in a very timely fashion and 4 development and curation of a public database of neurosciencerelevant phenotypic information from mutant strains In addition to the above the contract shall also contain an option for the performance of additional services The additional services that could be required include the baseline phenotyping of nine inbred strains 129SvlmJ AJ BALBcJ BTBR C3HHeJ C57BL6J CASTEi DBA2J and FVBNJ on neurosciencerelevant domains mapping of mutations to a higher resolution than originally done by the three mutagenesis facilities and breeding of mutations into balanced and congenic stocks on specified genetic backgrounds for distribution to the scientific community To eliminate the potential for patents on mutant mice and cryopreserved materials that would undermine the development of a widely available national resource the successful offeror must agree to abide by the terms and conditions imposed by the employment of FAR Clauses 5222711 Patent Rights Deviation and 5222714 Rights in DataGeneral Deviation Request for Proposal RFP No NIMH01DN0018 will be available on or about June 19 2001 and receipt of proposals will be due on or about November 9 2001 The RFP may be accessed electronically through the NIMH Homepage at httpwwwnimhnihgov First click on Funding Opportunities then click on Contracts and scroll down to the RFP Number This RFP may also be accessed electronically at FEDBIZOPPS at httpwwwfedbizoppsgov Please note that the RFP for this requirement will include the Statement of Work Deliverables and Reporting Requirements Technical Evaluation Criteria and the Proposal Preparation Instructions All information required for the submission of an offer will be contained in the electronic RFP package Following proposal submission and the initial review process offerors included in the competitive range will be requested to provide additional documentation to the Contracting Officer All responsible sources may submit a proposal that will be considered by the NIMH This advertisement does not commit the Government to award a contract
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